IndraLab

Statements

OTUB1 inhibits STAT1. 6 / 6
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"We hypothesized that OTUB1 potentially inhibits the JAK/STAT1 pathway activity promoting the development of GBM."
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"In summary, OTUB1 might inhibit the JAK2/STAT1 pathway in the context of GBM."
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"OTUB1 inhibited the JAK2/STAT1 pathway promoting GBM cell growth."
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"These findings indicated that OTUB1 inhibits the JAK2/STAT1 signaling pathway in the context of GBM, promoting cell growth and influencing various biological behaviors."
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"In GBM, several previous studies have shown that OTUB1 may act as an oncogene, but its specific regulatory mechanisms need to be further explored.The present study discovered a novel mechanism by which OTUB1 inhibits the JAK2/STAT1 signaling pathway."
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"The addition of the JAK2 inhibitor AZD1480 significantly reversed the effects of silencing OTUB1 on GBM.Conclusion: Our study reveals a novel mechanism by which OTUB1 inhibits the JAK2/STAT1 signaling pathway."
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