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Colchicine inhibits NLRP3. 44 / 44
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"Indeed, colchicine is known to block the NLRP3 inflammasome and has many advantages, such as a limited immunosuppression, oral administration, and few side effects."
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"Meanwhile, colchicine can prevent NSAID enteropathy by inhibiting the activation of NLRP3 inflammasome (Otani et al., 2016)."
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"In a mouse model of AMI, treatment with oral colchicine (0.1 mg/kg/d for 7 consecutive days) significantly reduced activation of the NLRP3 inflammasome and expression of downstream pyroptosis-related proteins of NLRP3 after 24 h."
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"Colchicine, a very cheap drug, can effectively block NLRP3 inflammasomes and reduce inflammation."
34312998
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"In both CVB3 FB and HL-1 cells, colchicine down-regulated the NLRP3 inflammasome-related components ASC, caspase-1, and IL-1β."
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"Colchicine suppresses NLRP3 inflammasome, by disrupting the microtubule‐dependent transport of mitochondria to the endoplasmatic reticulum, whose assembly with its adaptor and NLRP3 is required to be activated with inflammasomes (Lopes et al., 2021)."
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"Martinon F. et al. proved that colchicine can inhibit the activation of the NLRP3 inflammasome in cultured monocytes.34 Current studies have shown that the mechanism of colchicine on the NLRP3 inflammasome can be summarized into the following three types.3.2.1 Colchicine can restrict P2X7 receptor."
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"Thus, colchicine inhibits P2X7R, P2X2R, and consequently NLRP3 inflammasome which ultimately attenuates cytokine storm.Antidepressants (paroxetine, duloxetine, fluoxetine) (P2X4 inhibitor)Anti-inflammatory impacts of some antidepressant groups, such as selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs), are a portion of their therapeutic application [132] [133] [134] ."
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"In a murine myocardial infarct model, with doses comparable to those employed in humans (0.1 mg/kg), colchicine attenuated the activation of NLRP3 inflammasome constituents over and above the decrement in inflammatory mediators [9,91,92]."
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"We show that colchicine applied in the early phase of viral infection decreases splenic NLRP3 inflammasome activity, which was associated with lower myocardial immune cell infiltration and improved LV function."
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"Colchicine inhibits microtubule polymerization, as well as IL-1-, IL-6-, GM-CSF-, and NLRP3-dependent inflammasome activation."
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"Thus, colchicine inhibits P2X7R, P2X2R, and consequently NLRP3 inflammasome which ultimately attenuates cytokine storm."
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"36, 37 Colchicine downregulates multiple inflammatory pathways including the NLRP3 inflammasome implicated in acute lung injury 17, 38 and modulates innate immunity."
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"More importantly, an alkaloid drug Colchicine which is known for its effects such as tubulin disruption, alteration of E-selectin distribution on endothelial surfaces, inducing loss of adhesion molecule L-selectins and preventing adhesion and recruitment of neutrophil, has also been shown to inhibit activation of the NLRP3 inflammasome."
32574259
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"Finally, and based on studies carried out in microcrystalline arthropathies, it has been shown that colchicine suppresses the activation of the inflammasome (NLRP3) induced by calcium pyrophosphate and monosodium urate crystals."
34488841
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"While the mechanisms of action of colchicine to inhibit NLRP3 inflammasome remain an area of ongoing research, colchicine has been previously shown to inhibit the activation of NLRP3 inflammasome."
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"Figure 3: Colchicine abrogates splenic NLRP3 inflammasome activity in experimental Coxsackievirus B3‐induced myocarditis."
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"116 Colchicine inhibits NLRP3 through inhibiting the activation of P2X7 receptor and thereby the interaction between ASC and NLRP3 ; more specifically , the transportation of ASC to NLRP3 ."
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"However, it is unclear whether colchicine could suppress the activation of NLRP3 inflammasome and cell pyroptosis induced by CC in the progression of AS, and direct evidence for AMPK/SIRT1 activation in antagonizing inflammasome and pyroptosis is still lacking.In this study, we discovered that colchicine could upregulate the expression and activity of various antioxidant enzymes, inhibit ROS production and NLRP3 inflammasome activation, and antagonize endothelial cell pyroptosis which was induced by CC via activating the AMPK-SIRT1 pathway."
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"Colchicine can inhibit the activation of NLRP3 in the inflammasome and also directly inhibit the synthesis of TNF-α and IL-6 [156]."
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"Colchicine reduces the activation of NLRP3 inflammasome in COVID-19 patients."
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"In addition, previous studies have demonstrated that colchicine can reduce NALP3 inflammasome-driven caspase-1 activation by preventing microtubule assembly and MSU delivery (39)."
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"Colchicine downregulates multiple inflammatory pathways including the NLRP3 inflammasome implicated in acute lung injury [17,38] and modulates innate immunity [36,[39], [40], [41], [42]]."
34461322
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"At the molecular level, colchicine blocks the assembly of NLRP3 via preventing microtubule polymerization and inhibits the production of IL-8 and IL-1β, thereby inhibiting the process of inflammation."
35046517
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"Treatment with colchicine inhibited the activation of the NLRP3 inflammasome, an event triggering the 'cytokine storm' in COVID-19."
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"Additionally, several NLRP3 inflammasome inhibitors such as colchicine, OLT1177 and MCC950 have also been identified to inhibit the activity of ATPase and prevent the assembly and activation of NLRP3 inflammasome."
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"Colchicine, for example, disrupts different cellular processes including the NLRP3 inflammasome as well as processes leading to cytokine storm and was therefore investigated as a therapeutic option against COVID-19 [33], [34]."
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"Therefore, we considered that higher concentrations of nigericin might activate the inflammasome in the absence of the speck, but whether colchicine blockade of NLRP3:ASC speck assembly is overcome under these conditions is untested."
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"Finally, colchicine can also inhibit the activation of the NLRP3 inflammasome and reducing the pro‐inflammatory cytokines production."
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"Colchicine, an alkaloid derivative of the Colchicum genus plants, inhibits IL-1β and IL-18 by interacting with the inflammasome Nod-like receptor protein 3 inflammasome protein complex 1 (NLRP-3), for which it is hypothesized that it could be useful in severe Covid-19 Pneumonia [24]."
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"Colchicine at a dose of 0.5 mg once daily reduces inflammasome (NLRP3) activation and neutrophil degranulation (5, 6)."
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"Thus, colchicine inhibits P2X7R, P2X2R, and consequently NLRP3 inflammasome which ultimately attenuates cytokine storm.Anti-inflammatory impacts of some antidepressant groups, such as selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs), are a portion of their therapeutic application [132–134]."
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"However, a high dose of colchicine is required to inhibit the NLRP3 inflammasome, and the use of this treatment in patients with renal insufficiency may be limited by the risk of colchicine toxicity because of the increased half-life of the drug [249, 250] ."
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"al. observed that the levels of NLRP3, caspase-1 and IL-1β significantly increase in the small intestine upon indomethacin induced small intestine injury, and colchicine could inhibit the activation of NLRP3 inflammasome [299]."
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"Figure 2: Colchicine reduces the presence of NLRP3 inflammasome‐expressing cells in the left ventricle of experimental Coxsackievirus B3‐induced myocarditis."
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"Conversely, colchicine treatment significantly blocked NLRP3 signal activity; the expression levels of NLRP3 and ASC-1 were nearly half compared with the CC group (Figures 2(b) and 2(c))."
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"Since colchicine inhibits the NLRP3 inflammasome, it has been postulated for use in SARS-CoV-2 infection [6]."
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"Moreover, colchicine downregulates NLRP3 inflammasome by antagonizing caspase-1 activity and potential triggering factors (e.g., P2X2 and P2X7 channels and Reactive Oxygen Species) (104)."
31681717
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"Colchicine may inhibit activation of NLRP3 inflammasome and additionally may inhibit directly the synthesis of TNF-α and IL-6 [93]."
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"However, colchicine is a microtubule inhibitor and potentially inhibits the NLRP3 inflammasome at various points [2, 19] and has been shown to reduce pro-inflammatory cytokines including interleukin-1β (IL-1β), interleukin-18 (IL-18) and interleukin-6 (IL-6), as well as the inflammatory marker C-reactive protein (CRP) in a variety of experimental models and clinical settings [2, 19]."
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"Apart from its effect on neutrophil activity, colchicine can indirectly block the NLRP3 inflammasome [20, 21], a macromolecular complex that senses danger and triggers a local or systemic inflammatory response by releasing pro-inflammatory cytokines, such as IL-1β [22]."
35113170
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"More recently, colchicine has been shown to decrease cytokine production by inhibiting activation of the NLRP3 inflammasome (figure 5)."
33293273
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"In recent years, colchicine was found to inhibit NLRP3 inflammasome, although the exact mechanism of action is not fully understood yet."
35113170
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"Therefore, it is plausible to suppose that colchicine may upregulate the expression and activity of various antioxidant enzymes and reduce the production of ROS via activating the AMPK-SIRT1 pathway, thus restraining the activation of NLRP3 inflammasome and endothelial cell pyroptosis induced by CC."
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