IndraLab

Statements

Hydroxychloroquine inhibits calcium(2+). 22 / 22
| 3 19
reach
"Therefore we performed in-vitro studies to validate whether HCQ could inhibit sustained Ca 2+ storage release after ionomycin stimulation."
28793932
eidos
"This observation suggests that HCQ could block calcium but also especially voltage dependent potassium channels ."
32402475
reach
"In contrast, within 5 days 400 mg of hydroxychloroquine daily lowered elevated levels of calcium and 1,25-(OH) 2D by 37% and 72%, respectively, in a hypercalcemic patient with sarcoidosis."
10022456
reach
"Hydroxychloroquine inhibits calcium signals in T cells : a new mechanism to explain its immunomodulatory properties."
10828029
reach
"In conclusion, our results show that HCQ inhibits Ca ++ -activated K + channels."
28507328
reach
"Strikingly, anti-TCR-crosslinking-induced calcium mobilization was significantly inhibited by HCQ, particularly at the highest concentrations tested (100 micromol/L) in both T-cell lines and primary T cells."
10828029
reach
"Here we show that HCQ inhibits Ca ++ -activated K + channels probably leading to impaired inflammasome activation."
28507328
reach
"Our results show that HCQ inhibits Ca ++ -activated K + channels."
28507328
reach
"At 3 µM and 10 μM, in addition increasing beat interval, HCQ decreased the L-type Ca 2+ and the rapidly activating potassium currents with a further decrease in I f ."
35634151
reach
"Thus, the inhibition of Ca ++ -activated K + channels by HCQ may lead to impaired inflammasome activation."
28507328
eidos
"Altogether , these studies show that blocking Ca 2 + release from the ER by HCQ leads to a multilevel inhibition of T-and B-cell activation , thereby hindering the immune response ( Fig 2 ) ."
32715647
reach
"Taken together, our results show that HCQ inhibits Ca ++ -activated K + channels probably leading to impaired inflammasome activation."
28507328
reach
"Chloroquine and hydroxychloroquine inhibit L-type Ca 2+ channels, since they decrease the amplitude of I Ca-L in sino-atrial (SA) XREF_BIBR and in working myocardial cells XREF_BIBR."
32565195
reach
"Hydroxychloroquine inhibits activated K + and Ca ++ channels."
33416933
reach
"Both CQ and HCQ are known hERG-blockers, but also block a variety of other ion channels including sodium, calcium, I K1 potassium and pacemaker funny channels(4)."
| DOI
reach
"This observation suggests that HCQ could block calcium but also especially voltage dependent potassium channels."
32402475
reach
"HCQ causes the blockage of sodium, calcium, and potassium channels of the cardiac myocyte."
33316045
reach
"Electrophysiology experiments demonstrated that HCQ inhibited Ca ++ -activated K + conductance in THP-1 macrophages in a dose dependent manner."
28507328
reach
"The previous study demonstrated that HCQ inhibited the free Ca 2+ exflux in Jurkat cell lines and T cells [XREF_BIBR]."
28793932
reach
"44 Also, HCQ may disrupt T-cell receptor crosslinking dependent calcium signaling."
21871597
eidos
"HCQ also inhibits Ca 2 + - activated K + channels in macrophages , and consequently K + efflux , which could result in impaired inflammasome activation and pro-inflammatory cytokine release ( Eugenia Schroeder et al , 2017 ) ."
32715647
reach
"17 HCQ also inhibits calcium signaling in T cells."
21689773