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Hydroxychloroquine inhibits calcium(2+). 30 / 30
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"Hydroxychloroquine is thought to inhibit increases in intracellular calcium by both impeding the entry of extracellular calcium into cells, as well as by preventing the liberation of intracellular calcium stores (22)."
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"Electrophysiology experiments demonstrated that HCQ inhibited Ca ++ -activated K + conductance in THP-1 macrophages in a dose dependent manner."
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"Full concordance between mechanical contraction and Ca signal was demonstrated by adding a high dose of HCQ, which inhibited completely the Ca oscillations and cardiomyocyte contractions in an identical period."
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"In conclusion, our results show that HCQ inhibits Ca ++ -activated K + channels."
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"Schroeder et al. demonstrated that HCQ could inhibit Ca -activated K channels and suppress inflammasome activation [141]."
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"Here we show that HCQ inhibits Ca ++ -activated K + channels probably leading to impaired inflammasome activation."
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"Chloroquine and hydroxychloroquine inhibit L-type Ca 2+ channels, since they decrease the amplitude of I Ca-L in sino-atrial (SA) XREF_BIBR and in working myocardial cells XREF_BIBR."
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"This observation suggests that HCQ could block calcium but also especially voltage dependent potassium channels."
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"As hydroxychloroquine decreased the rise of Ca 2 + ions initiated by A23187 (i.e. by a receptor-bypassing stimulus), its direct interaction with calcium mobilisation may be presumed."
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"Taken together, our results show that HCQ inhibits Ca ++ -activated K + channels probably leading to impaired inflammasome activation."
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"Further, HCQ increased the LCR period (Fig. S4 D) but decreased the Ca signals of individual LCRs (Fig. S4 E) and their normalized amplitude (Table S7)."
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"HCQ causes the blockage of sodium, calcium, and potassium channels of the cardiac myocyte."
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"A study reported that HCQ could inhibit calcium-dependent signals in B and T cells by reducing store capacity and refiling [20]."
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"HCQ was shown to reduce I , the L-type Ca current, and the rapidly activating potassium current in isolated guinea pig SAN cells (Capel et al., 2015)."
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"In contrast, within 5 days 400 mg of hydroxychloroquine daily lowered elevated levels of calcium and 1,25-(OH) 2D by 37% and 72%, respectively, in a hypercalcemic patient with sarcoidosis."
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"Hydroxychloroquine inhibits activated K + and Ca ++ channels."
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"44 Also, HCQ may disrupt T-cell receptor crosslinking dependent calcium signaling."
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"Strikingly, anti-TCR-crosslinking-induced calcium mobilization was significantly inhibited by HCQ, particularly at the highest concentrations tested (100 micromol/L) in both T-cell lines and primary T cells."
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"The previous study demonstrated that HCQ inhibited the free Ca 2+ exflux in Jurkat cell lines and T cells [XREF_BIBR]."
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"Therefore we performed in-vitro studies to validate whether HCQ could inhibit sustained Ca 2+ storage release after ionomycin stimulation."
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"17 HCQ also inhibits calcium signaling in T cells."
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"Our results show that HCQ inhibits Ca ++ -activated K + channels."
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"Both CQ and HCQ are known hERG-blockers, but also block a variety of other ion channels including sodium, calcium, I K1 potassium and pacemaker funny channels(4)."
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"Furthermore, HCQ has been reported to significantly reduce L-type calcium current in isolated guinea-pig sinoatrial node myocytes at 3 µM concentration (Capel et al., 2015)."
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"The recent observation that HCQ decreases total calcium influx and calcium transient magnitude in cardiomyocytes (Oguntuyo et al., 2022; Segal et al., 2022), together with HCQ and AZM effect on calcium transient upstroke velocity in human induced pluripotent stem cell-derived cardiomyocytes (Charrez et al., 2021), further supports the ability of both drugs to reduce intracellular calcium concentration and affect contractility.HCQ and AZM can also act on several different ion channels and pumps in addition to L-type calcium channels."
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"Thus, the inhibition of Ca ++ -activated K + channels by HCQ may lead to impaired inflammasome activation."
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"Hydroxychloroquine inhibits calcium signals in T cells : a new mechanism to explain its immunomodulatory properties."
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"This observation suggests that HCQ could block calcium but also especially voltage dependent potassium channels ."
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"Since HCQ exerted inhibitory effects on MCs, we speculated that HCQ could inhibit MrgprB2/KCa3.1-mediated the calcium influx in MCs."
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"Compared with the AUC of 2-APB activation (22.92 ± 1.44), 100 μM HCQ significantly inhibited calcium ion entry with an AUC of 8.65 ± 0.83 and 300 μM HCQ virtually eliminated all calcium entry with an AUC of 0.28 ± 0.05, while the AUC of positive control ionomycin was 41.59 ± 1.50.To investigate the inhibitory mechanism of HCQ, we performed single-channel recordings of TRPV3 in the inside-out configuration (Fig. 2, G–J)."
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