IndraLab

Statements

Rosuvastatin inhibits KCNH2. 5 / 6
1 | 5
reach
"Drug efflux mediated via P-glycoprotein modulates the inhibition of hERG currents by ibutilide (McBride et al. 2009), dofetilide (Hreiche et al. 2009), and rosuvastatin (Plante et al. 2012)."
35763054
reach
"Since chemical structure of rosuvastatin is similar to that of several IKr blockers (ibutilide and E-4031), the present study aimed to reveal the mechanism that underlies rosuvastatin induced hERG current reduction and to evaluate the possibility of cardiac toxicity."
30807184
reach
"The results showed that rosuvastatin reduced hERG currents by accelerating the inactivation and prolonged action potential duration (APD) in hiPSC-CMs."
30807184
reach
"Some studies have shown that rosuvastatin blocks the hERG channel and prolongs QT intervals in vitro, ex vivo, and in vivo ."
37208484
reach
"Rosuvastatin blocks hERG current and prolongs cardiac repolarization."
22081364