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USP19 inhibits pTh17 differentiation. 1 / 1
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eidos
"Taken together , USP19 suppresses pTh17 differentiation and pathogenic potential through the removal of K63-linked ubiquitin chain from lysine 313 of RORgammat , which is required for recruiting coactivator SRC3 and essential for the expression of proinflammatory effectors ( Fig. 6E ) ."