IndraLab

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VEGFA binds CRIM1. 8 / 8
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"Our previous work showed that Crim1 binds and regulates VEGF-A activity in vivo, with Crim1 KST264 and KST264 displaying excessive VEGF-A diffusion away from the podocytes of the renal glomerulus (where Crim1 and VEGF-A are co-expressed), resulting in increased activation of VEGFR-2 in adjacent vascular endothelial cells."
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"Combined, these data support a model in which CRIM1 regulates VEGFA autocrine activity in the previously defined ‘private loop’ ( xref ) and is consistent with the observation that Crim1 can form physical complexes with Vegfa ( xref )."
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"It has also been shown that CRIM1 is able to interact with VEGFA, suggesting that CRIM1 modulates the delivery of VEGFA from the podocytes to the glomerular endothelial cells, thus regulating the release of this growth factor from the site of production [ xref ]."
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"Based on known Vegfa binding by Crim1 and Crim1 expression in retinal vasculature, where angiogenesis is known to be Vegfa dependent, we tested the hypothesis that Crim1 is involved in the regulation of Vegfa signaling."
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"Another study has provided evidence that Crim1 can physically bind signaling ligands such as Vegfa, Pgf or Pdgf before their secretion ( xref )."
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"Based on known Vegfa binding by Crim1 and Crim1 expression in retinal vasculature, where angiogenesis is known to be Vegfa dependent, we tested the hypothesis that Crim1 is involved in the regulation of Vegfa signaling."
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"In the current study, based on the known Vegfa binding by Crim1 and the expression of Crim1 in retinal vasculature, we tested the hypothesis that Crim1 is involved in the autocrine activity of Vegfa."
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sparser
"In the current study, based on the known Vegfa binding by Crim1 ( xref ) and the expression of Crim1 in retinal vasculature, we tested the hypothesis that Crim1 is involved in the autocrine activity of Vegfa."
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