IndraLab

Statements

USP15 activates IL6. 2 / 2
| 2
reach
"Importantly, Hrd1 deficiency in macrophages protects mice against lipopolysaccharide induced septic shock, and knockdown of Usp15 in Hrd1-knockout macrophages restores the reduced IL-6 production."
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reach
"Mechanistically, we find that USP15 functions in a haploinsufficient manner and that loss of USP15 or SCAF1 leads to reduced inflammatory TNFalpha, TGF-beta and IL6 responses and increased sensitivity to PARP inhibition and Gemcitabine."
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