IndraLab

Statements

USP10 activates reactive oxygen species. 4 / 4
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"USP10-knockout indicated that USP10, through augmenting formation of SGs, reduced reactive oxygen species (ROS) production and inhibited ROS dependent apoptosis."
| PMC
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"Since aberrant ROS production has been shown to be a critical apoptosis inducer of HSCs under basal and stress conditions, it was initially assumed that USP10 inhibits apoptosis of HSCs by inhibiting ROS production."
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"For example, inhibiting USP10 reduces the production of reactive oxygen species and suppresses apoptosis and the formation of SGs (stress granules) [78]."
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"We showed previously that USP10-KD increases the production of ROS by an oxidant (arsenite)."
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