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SLC7A11 activates OTUB1. 2 / 2
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"Studies have shown that CD44 promotes the deubiquitination of SLC7A11 by promoting the binding of the deubiquitination enzyme OTUB1 to SLC7A11, thus making SLC7A11 on the cell membrane stable against proteasome pathway degradation [28]."
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"Notably, Ferrostatin-1 restored the expression levels of SLC7A11, which had been markedly decreased due to OTUB1 knockout (Fig. 3A)."
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