IndraLab

Statements

USP4 inhibits SOX9. 2 / 2
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"Interestingly, downregulation of SOX9 in CRC cells that were induced by USP4 siRNA was rescued by MG132 treatment, which is a well-known proteasome inhibitor (Fig. 3B)."
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"Mechanistically, EVO directly interacts with USP4, thereby disrupting the protein stability of SOX9.In this study, we demonstrated that evodiamine inhibits colorectal cancer (CRC) stemness by disrupting USP4-mediated SOX9 stabilization, providing novel insights into the molecular mechanisms of CRC progression."
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