IndraLab

Statements

USP7 activates Neoplasm Metastasis. 14 / 15
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"Through clinical investigation, we detected that USP7 was significantly associated with positive lymph node metastasis, which indicated that USP7 may promote EOC metastasis."
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"Usp7 promotes medulloblastoma cell survival and metastasis by activating Shh pathway."
28137592
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"However , our previous studies show that HAUSP promotes medulloblastoma cell survival and metastasis via deubiquitinating the Gli54 ."
30679505
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"Both of USP7 and cyclin A2 synergistically promote the proliferation and metastasis of HCC cells, reducing intracellular DNA damage."
33869059
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"In HCC patients with high body fat percentages, the expression of circ-DB is upregulated, and circ-DB downregulates the expression of miR-34a by acting as a miRNA sponge, thus activating USP7, which can promote tumor growth and metastasis by reducing the ubiquitination of Cyclin A2 and many other proteins 68."
33627631
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"CARM1 and USP7 dependent LSD1 stabilization promotes invasion and metastasis of breast cancer cells [XREF_BIBR]."
33593309
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"In HCC patients with high body fat percentages , the expression of circ-DB is upregulated , and circ-DB downregulates the expression of miR-34a by acting as a miRNA sponge , thus activating USP7 , which can promote tumor growth and metastasis by reducing the ubiquitination of Cyclin A2 and many other proteins68 ."
33627631
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"Additionally, Liang et al. revealed that Usp7 regulates human terminal erythroid differentiation [22] and promotes the invasion and metastasis of cancer [25]."
33151468
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"Pharmacological inhibition of USP7 suppresses growth and metastasis of melanoma cells in vitro and in vivo."
34469054
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"Overall, USP7 overexpression could promote OS cell metastasis by activating the Wnt and beta-catenin signalling pathway by inducing EMT, suggesting that USP7 is a potential therapeutic target for OS."
30542736
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"A USP7 inhibitor effectively induced apoptosis and suppressed metastasis in chemoresistant TNBC ."
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"Moreover, USP7 expression was increased in patients with tumour-node-metastasis (TNM) stages III-IV, poor pathological grade, and positive lymph node metastasis."
34562828
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"Here we report that HAUSP (USP7) deubiquitinase deubiquitinates HIF-1alpha to increase its stability, induce epithelial-mesenchymal transition and promote metastasis."
27934968
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"USP7 promotes APL, aggressive prostate cancer, and NSCLC metastasis."
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