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USP7 activates Neoplasm Metastasis. 32 / 33
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"Meanwhile, the level of PD-L1 was also determined by IHC staining and it was found that inhibition of USP7 resulted into a significant inhibition of PD-L1 expression in both C33A and MS751 tumor tissu[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In HCC patients with high body fat percentages , the expression of circ-DB is upregulated , and circ-DB downregulates the expression of miR-34a by acting as a miRNA sponge , thus activating USP7 , which can promote tumor growth and metastasis by reducing the ubiquitination of Cyclin A2 and many other proteins68 ."
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"Overall, USP7 overexpression could promote OS cell metastasis by activating the Wnt and beta-catenin signalling pathway by inducing EMT, suggesting that USP7 is a potential therapeutic target for OS."
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"Inhibition of USP7 significantly counters resistance to Dox and paclitaxel in TNBC cells, thus diminishing tumorigenesis and distant metastasis in an orthotopic BC mouse model [93]."
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"Studies in mice have demonstrated that pharmacological inhibition of USP7 suppressed the growth and metastasis, promoted cancer cell death in vitro and in vivo [14, 15]."
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"For instance, USP7 was observed to accelerate osteosarcoma cell metastasis by inducing epithelial-mesenchymal transition [ 4 ]."
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"Pharmacological inhibition of USP7 suppresses growth and metastasis of melanoma cells in vitro and in vivo."
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"However , our previous studies show that HAUSP promotes medulloblastoma cell survival and metastasis via deubiquitinating the Gli54 ."
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"YY1 and USP7 promoted tumorigenesis and metastasis of colorectal carcinoma in vitro and in vivo."
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"Since our previous data have demonstrated that Usp7 positively regulates Hh pathway in Drosophila and mammalian cells [8] , it is fruitful to investigate whether Usp7 governs MB formation through trig[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Suppression of USP7 activity induces apoptosis and suppresses metastasis in estrogen receptor-positive breast cancer cells."
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"The combined inhibition of USP7 and CDK1 by GNE-6776 and Ro-3306 synergistically represses the malignant process and metastasis of ERPBC."
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"USP7 promotes APL, aggressive prostate cancer, and NSCLC metastasis."
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"Taken together, Usp7 positively regulates the proliferation and metastasis of MB cells, suggesting that Usp7 plays an oncogenic role in MBs.Although our previous data clearly showed that knockdown of [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Moreover, USP7 expression was increased in patients with tumour-node-metastasis (TNM) stages III-IV, poor pathological grade, and positive lymph node metastasis."
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"Notably, USP7 induces epithelial-mesenchymal transformation (EMT) and promotes metastasis."
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"Our findings showed that USP7 promotes tumor progression and metastasis of ERPBC via direct regulation of CDK1 stability."
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"For example, USP2 and USP7 modulate p53 and MDM2, impacting cell survival and tumor development, while USP22 stabilizes c-Myc, driving cancer proliferation and metastasis [9–13]."
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"Taken together, these results illustrate that Usp7 promotes the proliferation and migration of MB cells through stimulating Shh pathway.Given that Usp7 promotes MB cell proliferation and metastasis, a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Here we report that HAUSP (USP7) deubiquitinase deubiquitinates HIF-1alpha to increase its stability, induce epithelial-mesenchymal transition and promote metastasis."
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"Suppression of USP7 expression can inhibit the growth and metastasis of melanoma cells both in vitro and in vivo [33]."
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"Additionally, Liang et al. revealed that Usp7 regulates human terminal erythroid differentiation [22] and promotes the invasion and metastasis of cancer [25]."
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"In addition, USP7 was found to stabilize LSD1, further inhibit the p53 signaling pathway, and promote tumorigenesis and metastasis of glioblastoma [34]."
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"These results provide Usp7 inhibitors as potential drugs for MB clinical treatment.In this study, we identified the deubiquitinase Usp7 promotes the proliferation and metastasis of MB cells."
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"Through clinical investigation, we detected that USP7 was significantly associated with positive lymph node metastasis, which indicated that USP7 may promote EOC metastasis."
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"USP7 Inhibitor Suppresses Metastasis of Chemoresistant TNBC."
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"In HCC patients with high body fat percentages, the expression of circ-DB is upregulated, and circ-DB downregulates the expression of miR-34a by acting as a miRNA sponge, thus activating USP7, which can promote tumor growth and metastasis by reducing the ubiquitination of Cyclin A2 and many other proteins 68."
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"Moreover, silencing of USP7 also markedly inhibited lung tumor metastases in mouse models."
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"Both of USP7 and cyclin A2 synergistically promote the proliferation and metastasis of HCC cells, reducing intracellular DNA damage."
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"A USP7 inhibitor effectively induced apoptosis and suppressed metastasis in chemoresistant TNBC ."
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"CARM1 and USP7 dependent LSD1 stabilization promotes invasion and metastasis of breast cancer cells [XREF_BIBR]."
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"To assess the metastasis potential of these three groups of RMS cells, various studies were performed, showing that decreased USP7 expression in RD and A204 cells significantly inhibited RMS cell invasion and metastasis."
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