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(E)-3-tosylacrylonitrile inhibits NLRP3. 6 / 6
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"Interestingly, the IkappaB kinase-beta inhibitor Bay-11-7082 was found to potently inhibit the NLRP3 inflammasome, most likely through inhibiting the NLRP3 ATPase activity [XREF_BIBR]."
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"It is particularly interesting that BAY-117082 is known to prevent the organization of the ASC pyroptosome and NLRP3 inflammasome function through the alkylation of the cysteine residues of the NLRP3 ATPase region [27]."
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"Our results indicated that BAY-11-7082 could inhibit NLRP3 inflammasome activation to inhibit caspase-1-dependent pyroptosis and the inflammatory response, thus alleviating MI/R injury in diabetic rats and H/R injury in HG condition H9C2 cells."
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"Besides using antibodies against inflammasome components a recent study showed that Bay-11-7082 and Parthenolide, both NF-κB pathway inhibitors were able to inhibit NLRP3 receptor ATPase activity, whi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"We then used the NF-kappaB inhibitor BAY11-7082 to inhibit the expression of NF-kappaB , and the results indicated that BAY11-7082 could reduce NLRP3 protein expression ( Figure 8A and B , * * P < 0.01 ) ."
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"BAY-117082 Treatment Reduced NLRP3 Inflammasome Pathway Activation in OSCC Metastasis in Lung and Spleen."
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