IndraLab

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(E)-3-tosylacrylonitrile inhibits NLRP3. 4 / 4
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"Interestingly, the IkappaB kinase-beta inhibitor Bay-11-7082 was found to potently inhibit the NLRP3 inflammasome, most likely through inhibiting the NLRP3 ATPase activity [XREF_BIBR]."
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"Our results indicated that BAY-11-7082 could inhibit NLRP3 inflammasome activation to inhibit caspase-1-dependent pyroptosis and the inflammatory response, thus alleviating MI/R injury in diabetic rats and H/R injury in HG condition H9C2 cells."
29062465
eidos
"We then used the NF-kappaB inhibitor BAY11-7082 to inhibit the expression of NF-kappaB , and the results indicated that BAY11-7082 could reduce NLRP3 protein expression ( Figure 8A and B , * * P < 0.01 ) ."
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"By inhibiting ERK and NF-κB, U0126 and BAY 117082 inhibited mir-21 over-expression-induced activation of the NLRP3 inflammasome complex."
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