IndraLab

Statements

Ketanserin inhibits KCNH2. 4 / 4
| 4
reach
"Ketanserin blocked hERG current (I (hERG)) in a concentration dependent manner (IC50 = 0.11 microM)."
18574455
reach
"In conclusion, ketanserin blocks WT HERG currents in voltage- and concentration dependent manner and preferentially blocks open-state HERG channels."
18690396
reach
"The results showed that ketanserin blocked WT HERG currents in voltage- and concentration dependent manner and showed minimal tonic blockade of HERG current evaluated by the envelope of tails test."
18690396
reach
"These results suggest that ketanserin binds to and blocks the open hERG channels in the pore helix and the S6 domain; channel inactivation is also involved in the blockade of hERG channels."
18574455