IndraLab

Statements

Ketanserin inhibits KCNH2. 4 / 4
| 4
reach
"In conclusion, ketanserin blocks WT HERG currents in voltage- and concentration dependent manner and preferentially blocks open-state HERG channels."
18690396
reach
"Ketanserin blocked hERG current (I (hERG)) in a concentration dependent manner (IC50 = 0.11 microM)."
18574455
reach
"These results suggest that ketanserin binds to and blocks the open hERG channels in the pore helix and the S6 domain; channel inactivation is also involved in the blockade of hERG channels."
18574455
reach
"The results showed that ketanserin blocked WT HERG currents in voltage- and concentration dependent manner and showed minimal tonic blockade of HERG current evaluated by the envelope of tails test."
18690396