IndraLab

Statements

BAP1 inhibits inflammatory response. 3 / 3
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"Recent findings by Souri et al., concluded that loss of chromosome 3 and BAP1 expression correlated with the upregulation of the NF-κB (NF-κB1, NF-κB2, and RELB) signaling pathway and consequently promotes inflammation in UM tumors ."
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"For example, loss of the CDKN2A locus has been linked to immune evasion and reduced immunotherapy responses [54], while loss of BAP1 promotes TME inflammation, suggesting its potential as a biomarker for improved immunotherapy response [55]."
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"Loss of Bap1 increases tumor inflammation."
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