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Celastrol inhibits IRF3. 3 / 3
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"In 2020, our group found that celastrol could inhibit IRF3 activation in vitro and in vivo, thus effectively inhibits exogenous DNA-induced IFN-I response, with an IC value of 145.7 ± 23.6 nM (Liu et al., 2020)."
34867409
eidos
"In 2020 , our group found that celastrol could inhibit IRF3 activation in vitro and in vivo , thus effectively inhibits exogenous DNA-induced IFN-I response , with an IC50 value of 145.7 + / - 23.6 nM ( Liu et al ., 2020 ) ."
34867409
reach
"Here we showed that celastrol caused inhibition of interferon regulatory factor 3 (IRF3) activation leading to the down-regulation of the interferon response triggered by cytosolic nucleic acids in vitro and in vivo."
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