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Celastrol inhibits IRF3. 4 / 4
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"In 2020 , our group found that celastrol could inhibit IRF3 activation in vitro and in vivo , thus effectively inhibits exogenous DNA-induced IFN-I response , with an IC50 value of 145.7 + / - 23.6 nM ( Liu et al ., 2020 ) ."
34867409
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"In 2020, our group found that celastrol could inhibit IRF3 activation in vitro and in vivo, thus effectively inhibits exogenous DNA-induced IFN-I response, with an IC value of 145.7 ± 23.6 nM (Liu et al., 2020)."
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"We did not see the celastrol effect on TBK1, while our data showed that celastrol dramatically inhibited the constitutively active IRF3 activity."
32565148
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"Given that celastrol could inhibit the activation of both IRF3 and NF-κB, it might be a good drug candidate for treating SAVI diseases."
32565148