IndraLab

Statements

MYC activates USP22. 4 / 5
| 4
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"At the posttranscriptional level, c-MYC has been shown to increase USP22 protein but not mRNA levels."
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"Furthermore, USP22 acts as an enzymatic component of the SAGA transcriptional cofactor complex and is activated by Myc as an oncogene [38]."
| PMC
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"For example, as part of the SAGA complex USP22 promotes transcriptional activation by the Myc oncogene (Zhang et al., 2008b)."
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"This SIRT1 overexpression is related to enhanced expression of the USP22 deubiquitinase induced by c-MYC, leading to reduced SIRT1 ubiquitination and enhanced stability."
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