IndraLab

Statements

MYC activates USP22. 7 / 8
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"At the posttranscriptional level, c-MYC has been shown to increase USP22 protein but not mRNA levels."
27057639
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"Instead, the increased SIRT1 expression observed was linked to a myc-dependent induction of USP22 deuibiquitinase, leading to reduced SIRT1 ubiquitination and increase SIRT1 stability in leukemic cells."
36930820
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"For example, as part of the SAGA complex USP22 promotes transcriptional activation by the Myc oncogene (Zhang et al., 2008b)."
24647359
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"C-Myc induces the post-transcriptional upregulation of USP22, which stabilizes SIRT1 in LSCs [165]."
38397988
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"This SIRT1 overexpression is related to enhanced expression of the USP22 deubiquitinase induced by c-MYC, leading to reduced SIRT1 ubiquitination and enhanced stability."
25280219
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"SIRT1 overexpression is related to enhanced expression of the USP22 deubiquitinase induced by c-MYC, leading to reduced SIRT1 ubiquitination and enhanced stability, but inhibition of SIRT1 expression or activity reduced the growth of FLT3-ITD AML LSCs and significantly enhanced TKI-mediated killing of the cells."
37833921
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"Furthermore, USP22 acts as an enzymatic component of the SAGA transcriptional cofactor complex and is activated by Myc as an oncogene [38]."
| PMC