IndraLab

Statements

UCHL5 increases the amount of MYC. 5 / 5
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"Ubiquitin C-terminal hydrolase-L5 (UCHL5), a member of the DUBs family of proteins that is overexpressed in bladder cancer, has been indicated to promote the growth and migration of bladder cancer cells by increasing MYC expression through the AKT/mTOR signaling pathway [139]."
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"The growth and spread of BC cells are further accelerated by UCHL5, which activates the Akt pathway, increasing c-Myc expression [206]."
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"Deletion of UCH37 also down-regulated the transcription of c-Myc, a downstream effector of beta-catenin, and inhibited cell proliferation and motility."
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"Mechanistically, UCHL5 activates the AKT/mTOR signaling pathway and increases c-Myc expression, which promotes tumor occurrence and progression (124)."
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"In addition, our data indicate that UCHL5 increases c-Myc expression by activating the AKT/mTOR signaling pathway."
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