IndraLab

Statements

Paeoniflorin inhibits NLRP3. 7 / 7
| 1 6
reach
"In models of CCI-induced neuropathic pain, paeoniflorin was shown to inhibit NLRP3 and pro-IL-1β by inhibiting the regulation of NF-κB-mediated transcription."
35011486
reach
"In our study, paeoniflorin not only downregulated TLR4 but also suppressed the downstream inflammation related effectors NF-kappaB, NLRP3, caspase-1, and pro-IL-1beta."
29740218
reach
"Paeoniflorin can also inhibit NLRP3 inflammasome activity is a necessary component of the innate immune response to tissue damage."
35011486
reach
"Paeoniae alba has obvious analgesic, anti-inflammatory and immune regulating effects, and its active ingredient paeoniflorin can downregulate the NLRP3 inflammasome pathway to reduce inflammation, has a 2-way regulatory effect on the value-added of immune cells, and can reduce the production and release of prostaglandin E2 in the cerebral cortex, and is often used clinically to treat and relieve various types of pain and immune disorders."
36820580
reach
"Further in vitro evidence confirmed that paeoniflorin efficiently inhibited NLRP3 and NF-kappaB-mediated inflammation in DFU by inhibiting CXCR2."
33236457
reach
"In conclusion, paeoniflorin could inhibit abnormal activation of the NLRP3 inflammasome pathway by inhibiting miR-29a in IBS-D, thereby relieving the inflammatory response of the intestinal mucosa and reconstructing the intestinal epithelial barrier."
36590561
eidos
"Further in vitro evidence confirmed that paeoniflorin efficiently inhibited NLRP3 and NF-kappaB-mediated inflammation in DFU by inhibiting CXCR2 ."
33236457