IndraLab

Statements

Paeoniflorin inhibits NLRP3. 7 / 7
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"In conclusion, paeoniflorin could inhibit abnormal activation of the NLRP3 inflammasome pathway by inhibiting miR-29a in IBS-D, thereby relieving the inflammatory response of the intestinal mucosa and reconstructing the intestinal epithelial barrier."
36590561
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"Further in vitro evidence confirmed that paeoniflorin efficiently inhibited NLRP3 and NF-kappaB-mediated inflammation in DFU by inhibiting CXCR2."
33236457
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"Consistent with the results from molecular docking showing paeoniflorin antagonizes TLR4, NF-kappaB and NLRP3, the biochemical analysis also indicated paeoniflorin inhibited TLR4/NF-kappaB/NLRP3 signaling, decreased proinflammatory cytokine levels and microglial activation in the hippocampus of LPS induced mice."
33753146
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"In our study, paeoniflorin not only downregulated TLR4 but also suppressed the downstream inflammation related effectors NF-kappaB, NLRP3, caspase-1, and pro-IL-1beta."
29740218
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"Paeoniflorin can also inhibit NLRP3 inflammasome activity is a necessary component of the innate immune response to tissue damage."
35011486
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"In models of CCI-induced neuropathic pain, paeoniflorin was shown to inhibit NLRP3 and pro-IL-1β by inhibiting the regulation of NF-κB-mediated transcription."
35011486
eidos
"Further in vitro evidence confirmed that paeoniflorin efficiently inhibited NLRP3 and NF-kappaB-mediated inflammation in DFU by inhibiting CXCR2 ."
33236457