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USP17L2 activates Neoplasms. 5 / 5
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"Consistently, in vivo data showed that loss of DUB3 decreased tumor growth and Ki67 expression compared with that in the control group, whereas MAGEA3 overexpression reversed the inhibitory effect of DUB3 deficiency (Figures 4E, 4F, and 4H)."
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"Consistent with these in vitro findings, results from xenograft animal studies showed that knockdown of DUB3 inhibited tumor growth and increased sensitivity to cisplatin treatment."
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"Inhibiting Dub3 with the small molecule WP1130 destabilizes Snail, leading to a decrease in stemness in vitro and decreased tumor growth; however, there was no report of a decrease in metastasis or carcinoma progression (Fig. 8D) ."
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"USP17 Knockdown Impairs Tumor Proliferation and Metastasis Through Targeting MMPs Because degradation of the basement membrane by MMPs is required for tumor cell migration and invasion ( 16,17 ) , we sought to determine whether MMPs were responsible for USP17-dependent growth and invasion ."
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"DUB3 promotes tumor progression of HCC through stabilizing YAP1."
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