IndraLab

Statements

USP4 activates Wnt. 6 / 7
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"In addition to these newly identified nuclear functions, both USP4 and USP15 are well known to function in the cytosol, i.e. USP4 modulates the Wnt and beta-catenin, NF-kappaB, p53 and TGF-beta signaling pathways while USP15 performs functions in the TGF-beta receptor and NF-kappaB signaling pathways."
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"However , later studies demonstrated that USP4 enhanced Wnt signaling through stabilizing and facilitating nuclear localization of beta-catenin , especially in cancer ( Yun et al ., 2015 ; Hwang et al ., 2016 ) ."
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"( D ) Wnt signaling : USP4 enhances Wnt signaling through deubiquitinating and stabilizing P-catenin ."
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"However, later studies demonstrated that USP4 enhanced Wnt signaling through stabilizing and facilitating nuclear localization of beta-catenin, especially in cancer."
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"However, in contrast to the previous work RNAi depletion of USP4 caused an up-regulation of Wnt signalling."
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"According to a study , USP4 activates Wnt signaling by deubiquitinating and stabilizing beta-catenin ( Yun et al ., 2015 ) ."
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