
IndraLab
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reach
"Furthermore, swapping of this central residue of the " activation triplet " within the transmembrane domain between MinK and MiRP2 bestows the activation properties of either subunit on complexes formed with KCNQ1; T58V-MinK and KCNQ1 complexes exhibit a degree of constitutive activation, whereas V72T-MiRP2-KCNQ1 complexes produce slowly activating currents."