IndraLab

Statements


USP22 increases the amount of EGFR. 2 / 2
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"These results indicate that USP22 upregulates EGFR protein levels via enhancing EGFR stability."

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"In lung adenocarcinoma, USP22 can induce EGFR-TKI resistance by regulating the endocytosis and transport of EGFR through deubiquitination modification, stabilising the intracellular EGFR protein levels and promoting the continuous activation of EGFR-dependent signalling pathways (112)."