IndraLab

Statements

USP7 activates CLSPN. 4 / 7
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"USP7 targets Claspin, another damage response mediator protein, to prevent its degradation."
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"USP7 counteracts SCFbetaTrCP- but not APCCdh1 mediated proteolysis of Claspin."
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"All of these compounds were shown to abrogate the effects of Usp7 on p53, they also inhibit the enhanced tumourigenicity of claspin caused by Usp7 activity and increase apoptosis in cancer cells [XREF_BIBR]."
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"Since this initial discovery, USP7 has also been shown to destabilize or otherwise compromise the effectiveness of a number of critical tumor suppressors including p53, forkhead box protein O4 (FOXO4)[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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