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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

USP7 activates CLSPN. 3 / 6

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"USP7 targets Claspin, another damage response mediator protein, to prevent its degradation."

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"USP7 counteracts SCFbetaTrCP- but not APCCdh1 mediated proteolysis of Claspin."

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"All of these compounds were shown to abrogate the effects of Usp7 on p53, they also inhibit the enhanced tumourigenicity of claspin caused by Usp7 activity and increase apoptosis in cancer cells [XREF_BIBR]."

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INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...

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Statements

USP7 activates CLSPN. 3 / 6

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