IndraLab

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USP7 activates CLSPN. 3 / 6

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"USP7 targets Claspin, another damage response mediator protein, to prevent its degradation."

25578727

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"USP7 counteracts SCFbetaTrCP- but not APCCdh1 mediated proteolysis of Claspin."

19124652

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"All of these compounds were shown to abrogate the effects of Usp7 on p53, they also inhibit the enhanced tumourigenicity of claspin caused by Usp7 activity and increase apoptosis in cancer cells [XREF_BIBR]."

25962961

INDRA sources:

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USP7 activates CLSPN. 3 / 6

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