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USP22 deubiquitinates SPI1. 4 / 4
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"USP22 can deubiquitinate SPI1 to transcriptionally upregulate PD-L1."
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"USP22 deubiquitinates SPI1 and enhances its stability, thereby regulating PD-L1 expression."
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"Mechanistically, SPI1 serves as a transcription factor for PD-L1 and is deubiquitinated by USP22 (Fig. 3)."
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"33 , 34 In addition, USP22 can also deubiquitinate and stabilize the SPI1 protein, thereby enhancing PD‐L1 transcription and expression."
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