IndraLab

Statements

24,25-Dihydroxyvitamin D inhibits NLRP3. 6 / 6
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"* Vitamin D : In certain conditions, vitamin D has been found to decrease NLRP3 inflamasome activation XREF_BIBR and vitamin D receptor activation reduces IL-1b secretion."
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"In addition, vitamin D negatively regulates the NLRP3 inflammasome via VDR signaling to effectively inhibit IL-1beta secretion."
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"Progesterone and vitamin D downregulate the activation of the NLRP1 and NLRP3 inflammasomes and TLR4-MyD88-NF-kappaB pathway in monocytes from pregnant women with preeclampsia."
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"Indeed, vitamin C, vitamin D, and omega-3 fatty acids have all been shown to inhibit the NLRP3 inflammasome and may work synergistically against the cytokine storm associated with COVID-19 and specifically against the neuro inflammation associated with its delirium."
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"In an animal study, we found that NLRP3 activation was significantly correlated with damage to retinal cells and vascular permeability, whereas vitamin D 3 downregulated NLRP3, which subsequently reduced the rate of apoptosis and reduced vascular permeability in the retinas of diabetic rats."
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"Furthermore, vitamin D enhances VDR mediated inhibition of NLRP3 activation."
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