IndraLab

Statements

CALM activates KCNQ3. 3 / 3
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"Co-transfection with GFP tagged CaM or CaM 1234 did not increase KCNQ2-L586P and KCNQ3 currents (Figs. 6 B-C)."
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"Further, we show that CaM 1234 restores the assembly of KCNQ3 with the KCNQ2-L638P subunit which bears a mutation in its SI domain."
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"Recently, it has been shown by XREF_BIBR that KCNQ2 BNFS causing mutations express alterations in CaM binding and that in some cases CaM overexpression restored normal function of the KCNQ2 and KCNQ3 induced channels."
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