IndraLab

Statements

KCNMA1 inhibits cholesterol. 4 / 4
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"SLO sequesters cholesterol and induces a plasma membrane repair process that removes the pores via a lipid raft mediated endocytosis."
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"SLO sequesters cholesterol and induces a plasma membrane repair process that removes the pores via a lipid raft-mediated endocytosis ."
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"Consequently, SLO may sequester cholesterol molecules around the inserted channel, preventing major lipid disordering, a decrease in fluidity, and water penetration, thus weakening the optical response to SLO insertion."
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"Thus, our data buttress the idea that BK channel forming alpha subunits and a bare lipid environment (e.g., a binary phospholipid bilayer) are sufficient to support cholesterol induced reduction of BK channel activity."
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