IndraLab

Statements

P5091 decreases the amount of TP53. 3 / 3
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"In concert with these data, P5091 downregulated HDM2 and HDMX, as well as upregulated p53 and p21 levels, in scr-siRNA-transfected cells (XREF_SUPPLEMENTARY)."
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"P5091 decreased HDM2 and HDMX, as well as upregulated p53 and p21 levels (XREF_FIG)."
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"P5091 actively inhibits USP7 at concentrations as low as 5 - 10 muM in the cellular environment, resulting in HDM2 poly-ubiquitination and accelerated degradation by the proteasome, and consequently increased steady-state protein levels of p53 and p21."
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