IndraLab

Statements


USP22 deacetylates XRCC6. 7 / 7
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"USP22 can reduce Ku70 acetylation by stabilizing SIRT1 expression, thereby inhibiting Bax-mediated apoptosis and promoting cisplatin resistance.ALDH1A3, a major ALDH isoenzyme, is important for the stem cell signature of lung cancer and is associated with enhanced cisplatin resistance in lung adenocarcinoma."

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"USP22 Decreases the Acetylation of Ku70 by Stabilizing Sirt1, thus Inhibiting Bax Mediated Apoptosis and Inducing Cisplatin Resistance."

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"In addition, USP22 could also decrease the acetylation of Ku70 by stabilizing the expression of Sirt1, thus inhibiting Bax mediated apoptosis and contributing to cisplatin resistance."

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"These results suggest that USP22 decreases the acetylation of Ku70 by stabilizing Sirt1, thus inhibiting Bax mediated apoptosis and inducing cisplatin resistance."

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"(2) USP22 decreases the acetylation of Ku70 by stabilizing Sirt1, thus inhibiting Bax mediated apoptosis and inducing cisplatin resistance."

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"In addition, USP22 decreases the acetylation of Ku70 by stabilizing Sirt1, thus inhibiting Bax mediated apoptosis and inducing cisplatin resistance."

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"In addition, USP22 was shown to decrease the acetylation of Ku70 by stabilizing SIRT11 via deubiquitination."