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FTO increases the amount of USP7. 8 / 8
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"Fat mass and obesity associated protein (FTO), a demethylase that is significantly upregulated in NSCLC, can promote the expression of USP7 by activating its m6A demethylase activity, reducing the m6A level of USP7 and improving the stability of its mRNA (56)."
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"Collectively, these findings demonstrated that FTO promotes the expression of USP7 by demethylating its mRNA.Finally, we analyzed the roles of USP7 in human lung cancer cells."
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"FTO promoted the expression of USP7 by demethylating its mRNA and increasing the stability of USP7 mRNA.In conclusion, our findings demonstrate that the FTO-USP7 axis is critically involved in human N[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"We found that FTO knockdown reduced the mRNA and protein levels of USP7 in A549 cells ( Fig. 3 C and D)."
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"By contrast, overexpression of wild-type FTO increased the mRNA and protein levels of USP7 in lung cancer cells ( Fig. 3 E and F)."
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"FTO promotes proliferation and colony formation of lung cancer cells by increasing the expression of USP7 (ubiquitin specific protease 7)."
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"Besides, FTO could also mediate the m6A level of USP7 to facilitate the growth of NSCLC [ 26 ]."
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"Li et al.88 found that FTO promotes the proliferation of NSCLC by increasing the expression of USP7."
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