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"Functionally, TZD-dependent increase in SK-1 activity and intracellular S1P formation were associated with lower amounts of the pro-fibrotic factor, connective tissue growth factor (CTGF) [4] , which[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"A further consequence of PA formation by PLD is that this activates several signaling cascades including SK-1 and S1P formation ( Figs."

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"In this regard, it is well established that S1P 1 mediates cell migration and proliferation of various tumor cells, and an enhanced SK-1-dependent formation of S1P was found to be crucial for cancer [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"