IndraLab

Statements

USP29 activates sorafenib. 4 / 4
| 4
reach
"Gao et al. (84) found high USP29, HIF1α and GLUT1 levels in sorafenib-resistant PDX tumours, and follow-up research revealed that USP29-induced sorafenib resistance by mediating HIF1α stabilisation and upregulated glycolysis."
39144662
reach
"USP29 promotes sorafenib resistance in vivo."
34272356
reach
"USP29 promotes sorafenib resistance in HCC cells by stabilizing HIF1α [22]."
39355870
reach
"Together, the data demonstrate that, as a DUB of HIF1alpha, USP29 promotes Sorafenib resistance in HCC cells, in parts by upregulating glycolysis, thereby opening new avenues for therapeutically targeting Sorafenib-resistant HCC in patients."
34272356