IndraLab

Statements

USP9X decreases the amount of ICP0. 3 / 3
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"However, the mechanism by which USP9X downregulates ICP0 expression is unknown at present, although it is possible that USP9X deubiquitylates and stabilizes an unknown ICP0 interacting factor that downregulates ICP0."
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"Notably, ICP0 expression was downregulated by USP9X, in contrast to other USP9X interacting proteins."
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"These observations suggested that USP9X negatively regulates ICP0 expression to inhibit viral replication, although we can not exclude the possibility that USP9X may suppress HSV-1 replication through other pathways."
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