IndraLab

Statements

MZF1 activates KCNA2. 9 / 9
| 9
reach
"Mechanistically, MZF1 participated in CCI-induced reductions in Kv1.2 mRNA and protein and total Kv current and the CCI-induced increase in neuronal excitability through MZF1-triggered Kv1.2 AS RNA expression in the injured DRG neurons."
25630025
reach
"MZF1 promotes Kcna2 antisense RNA gene activity after SNL."
23792947
reach
"Mechanistically, MZF1 participated in CCI-induced reductions in Kv1.2 mRNA and protein and total potassium current and in the CCI-induced increase in neuronal excitability through MZF1-triggered Kv1.2 AS RNA expression in the injured DRG neurons."
25630025
reach
"Thus, MZF1-induced Kcna2 downregulation may be attributable to MZF1-triggered Kcna2 antisense gene expression."
23792947
reach
"We found that Kcna2 SE RNA fragment blocked MZF1-induced increase in Kcna2 antisense RNA and reversed MZF1-induced reduction in Kcna2 mRNA in DRG neurons (Fig. 5g)."
23792947
reach
"Contribution of MZF1-triggered Kv1.2 antisense RNA to nerve injury-induced DRG Kv1.2 downregulation."
25962909
reach
"MZF1 siRNA significantly blocked CCI-induced increases in MZF1 mRNA and protein and Kv1.2 AS RNA and rescued CCI-induced reductions in Kv1.2 mRNA and protein in the ipsilateral L DRGs on day 7 (Fig. 3) and day 14 (data not shown) post-CCI."
25630025
reach
"MZF1-mediated increase of Kcna2 AS RNA after nerve injury."
24739997
reach
"Mechanistically, MZF1 participated in CCI-induced reductions in Kv1.2 mRNA and protein and total Kv current and the CCI-induced increase in neuronal excitability through MZF1-triggered Kv1.2 antisense RNA expression in the injured DRG neurons."
25630025