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3',5'-cyclic AMP inhibits RELA. 5 / 5
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"We also tested the effects of CHF6001 on NF-κB via assessing nuclear translocation of phosphorylated NF-κB subunit p65, since NF-κB transcriptionally regulates cyclin D1 [ 24 ] and is inhibited by cAM[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
32268137
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"Elevated cAMP or NLS-Actin R62D reduced the half-life of RelA/p65, which was reversed by the proteasome inhibitor MG132."
35563720
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"The possibility was discussed that (p) ppGpp and cAMP both positively affect transcription of the genes encoding the acid sensitization components; in accord with this, high concentrations of cAMP suppressed the effect of the relA lesion of sensitization."
8676748
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"Elevated cAMP or NLS-Actin R62D reduced the half-life of RelA/p65, which was reversed by the proteasome inhibitor MG132."
35563720
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"Interestingly, PGE2 or di-butyryl (Bt2) cAMP abolished the binding of NF-kappa B (p50 and p65) heterodimer to the kappa B sequence in cells stimulated with anti-CD3 mAb but not with PMA and A23187."
8018594