IndraLab

Statements

COPS6 inhibits Neoplasm Invasiveness. 5 / 5
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"COPS6 promotes tumor progression and reduces CD8+ T cell infiltration by repressing IL-6 production to facilitate tumor immune evasion in breast cancer."
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"COPS6, a member of the JAMM family, has recently been verified to facilitate tumor advancement and decrease the infiltration of CD8 T-cells by suppressing the synthesis of IL-6, thus promoting tumor immune escape from cancer [44, 45]."
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"Furthermore, COPS6 was found to inhibit CD8+ T-cell infiltration in the tumor microenvironment, which facilitates tumor immune escape."
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"By regulating IL-6 secretion, p53/COPS6 reduces the infiltration and function of CD8 T cells, thus promoting the progression of breast cancer (27)."
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"This aligns with Du et al[28]’s results, demonstrating that COPS6 could inhibit CD8+ T cell infiltration within the tumor microenvironment (TME), thereby facilitating tumor immune evasion."
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