IndraLab

Statements

CYLD activates SMAD3. 5 / 5
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"Lim and co-workers showed that CYLD suppresses TGF-beta signalling and prevents lung fibrosis by (indirectly) reducing the stability of Smad3, in an AKT, GSK3beta and E3 ligase carboxy terminus of Hsc[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"CYLD inhibited transforming growth factor-beta-signalling and prevented lung fibrosis by decreasing the stability of Smad3 in an E3 ligase carboxy terminus of Hsc70 interacting protein dependent manner."
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"Finally, the deubiquitylase CYLD inhibits TGF-beta signaling by decreasing the stability of Smad3."
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"To further determine whether CYLD inhibits TGF-beta-signalling by likely targeting Smad3, we next evaluated the effect of CYLD knockdown in Smad3 deficient MEF cells."
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"This study proposes that CYLD inhibits TGFbeta signalling by decreasing the stability of SMAD3 via the AKT-GSK3-CHIP pathway."
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