IndraLab

Statements

USP8 binds TMEM79. 6 / 6
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"It seems conceivable that the Tmem79-Usp8 pair may have a primordial function in Wnt/FZD signaling in pre-bilaterians ( xref ; xref ), and that the pair have experienced losses in protostomes related to the loss of Wnt and Wnt antagonist genes."
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"TMEM79 is associated with USP8 and inhibits its deubiquitination of FZD."
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"Conversely TMEM79-USP8 interaction was unaffected in FZD null cells in which all 10 FZD genes have been deleted ( xref ; xref ), and is thus not mediated by FZDs."
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"Investigations in cnidarians and basal protostomes will help to address the origin of Tmem79-Usp8 specificity in Wnt/FZD signaling."
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"We therefore investigated TMEM79-USP8 biochemical and functional relationships."
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"We further performed a phylogenic analysis of the Usp8 gene given the Tmem79-Usp8 relationship we uncovered."
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