IndraLab

Statements


YOD1 deubiquitinates RAR. 2 / 2
| 2

reach
"Results reveal that purified YOD1 effectively deubiquitinated PML/RARα in vitro, while YOD1(C160S) failed to deubiquitinate PML/RARα (Fig. 3F), confirming the importance of YOD1 catalytic activity to PML/RARα deubiquitination."

reach
"In line with these results, YOD1 also notably downregulated the ubiquitination levels of drug-resistant PML/RARα mutants (ΔF286, R276Q, L218P and A216V) (Fig. 3E), strongly supporting that YOD1 may deubiquitination of PML/RARα."