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ANGPTL4 inhibits angiogenesis. 41 / 44
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"Takada et al. found that ANGPTL4 inhibited angiogenesis as a tumor suppressor (Okochi-Takada et al. 2014)."
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"However, its biology in experimental systems is still under debate as other studies show ANGPTL4 promotes endothelial barrier integrity, ameliorates tissue injury or tumor metastasis, and inhibits angiogenesis (26–29)."
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"In contrast, some studies have found no precise function for ANGPTL4 in cancer progression or even some of them discovered that the elevated expression of ANGPTL4 prevents tumor growth, invasion, and angiogenesis in melanoma and colorectal cancers 30."
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"ANGPTL4 induced neovascularization was not inhibited by the VEGF inhibitor PTK787/ZK 222584."
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"However, studies have also shown that increased ANGPTL4 expression inhibits melanoma, lung, and colorectal tumor growth, metastasis, and angiogenesis."
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"Yang et al. substantiated that ANGPTL4 inhibited angiogenesis by its carboxyl terminus (Yang et al. 2008)."
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"ANGPTL4 stimulates integrin-dependent survival signals through the activation of NADPH oxidase 1 (Nox1), mimics anchorage conditions and confers anoikis resistance to tumour cells by regulating oncogenic reactive oxygen species (ROS). xref Tumour-derived C-terminal ANGPTL4 (cANGPTL4) binds to integrin α5β1 and activates the downstream PAK/Rac signalling pathway, resulting in endothelial disruption in TGFβ-enhanced lung metastasis of breast cancer. xref , xref However, previous studies have shown that ANGPTL4 inhibits angiogenesis and prevents metastasis, xref , xref highlighting a controversial effect of ANGPTL4 on tumour metastasis."
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"Based on these results, we conjectured that IL-7 stimulated HDF secretion of ANGPTL4, which could inhibit HUVEC angiogenesis."
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"Compared with the IgG group, neutralizing antibodies promoted angiogenesis and wound healing.In summary, our present study corroborated that high glucose activates the IL-7- IL-7R signal pathway of HDF and promotes HDF secretion of ANGPTL4, which inhibits the angiogenesis of HUVEC."
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"In OC, it has been shown that ANGPTL4 reduces angiogenesis, thereby inhibiting tumor growth [18]."
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"In diabetes conditions, the expression of angiopoietin-like 4 is gradually reduced resulting in impaired angiogenesis and re-epithelization and hence diabetes associated wounds take longer to heal [ 1[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"It has been reported that the C-terminal domain of ANGPTL4 protein inhibits vascular epithelial growth factor (VEGF) and basic fibroblast growth factor (bFGF)-mediated angiogenesis [XREF_BIBR], and SNP rs1044250 is capable of altering the activity of ANGPTL4 C-terminus, therefore, the SNP rs1044250 may lead to a decreased angiogenesis and dysfunctional endothelial repairment."
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"ANGPTL4 promoted tumor apoptosis and inhibits tumor angiogenesis."
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"Finally, we tested the expression of Lyve-1 and CD34 to confirm the effects on lymphangiogenesis and angiogenesis in xenografts and showed that ANGPTL4 increased the level of lymphangiogenesis and angiogenesis in MKN7 cells but reduced the level of angiogenesis in AGS cells (Fig. 6D)."
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"This suggested ANGPTL4 can suppress angiogenesis of HCC."
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"Okochi-Takada and his colleagues suggested that ANGPTL4, a secreted protein, inhibited angiogenesis to impede GC growth ."
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"On the other hand, several studies showed that increased ANGPTL4 expression could inhibit tumor growth, metastasis, and angiogenesis in melanoma, lung, and colorectal cancers [XREF_BIBR, XREF_BIBR]."
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"Collectively, these observations support a possible role for ANGPTL4 in the promotion of metastasis in UM and provide a foundation for future studies to determine whether combined inhibition of both ANGPTL4 and VEGF could simultaneously target tumor induced angiogenesis and metastasis, and thereby provide more effective therapies for patients with primary and metastatic UM."
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"However, in melanoma, lung, and colorectal cancer, the induction of ANGPTL4 is reported to inhibit cell growth, angiogenesis, and metastasis [13]."
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"Under obesity, IL-1β from primary adipocytes could induce the angiopoietin-like 4 (ANGPTL4) expression through activation of NF-κB and mitogen-activated protein (MAP) kinases, therefore promoting angiogenesis and tumor suppression [38]."
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"It has been associated with inflammation due to elevated levels found in obese patients with type 2 diabetes mellitus.30 31 The ANGPTL4 protein reduces vascular permeability and inhibits angiogenesis and inflammatory signaling in various tissues.32 33 Furthermore, ANGPTL4 suppresses HUVECs tube formation and proliferation."
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"While some studies indicate that ANGPTL4 promotes tumorigenesis [XREF_BIBR, XREF_BIBR, XREF_BIBR], other studies suggest that ANGPTL4 inhibits angiogenesis and tumorigenesis [XREF_BIBR, XREF_BIBR, XREF_BIBR] (Box 2)."
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"In vivo, ANGPTL4 inhibits angiogenesis and vascular leakiness as well as melanoma cell motility and invasiveness to prevent metastasis."
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"However, several studies have claimed that ANGPTL4 inhibits vascular angiogenesis and prevents tumor metastasis in melanoma B16F0, lung cancer 3LL [XREF_BIBR] and colon cancer CMT93 [XREF_BIBR] xenograft mouse models; however, contrasting results were observed in breast cancer [XREF_BIBR], renal cell carcinoma [XREF_BIBR], and ovarian cancer [XREF_BIBR, XREF_BIBR] xenograft models, indicating that ANGPTL4 may act as a tissue specific and multifunctional vascular modulator."
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"Decreased ANGPTL4 impairs endometrial angiogenesis during peri-implantation period in patients with recurrent implantation failure."
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"Moreover, downregulating ANGPTL4 dramatically inhibited cancer cell angiogenesis and metastasis both in vitro and in vivo."
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"They showed that ANGPTL4 inhibits vascular endothelial growth factor (VEGF)-induced neovascularization."
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"They showed that ANGPTL4 inhibits vascular endothelial growth factor (VEGF)–induced neovascularization."
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"By knocking-out ANGPTL4 using TALENs method, osteoclastogenesis, osteolysis and angiogenesis induced by GCTSCs were significantly suppressed in vitro."
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"Various studies have also shown that ANGPTL4 expression prevents metastasis and angiogenesis by reducing vascular leakiness, cell motility and invasiveness in different neoplasm types, including melanoma, gastric, lung and colorectal tumors, as well as metastases [XREF_BIBR - XREF_BIBR]."
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"By contrast, in melanoma, lung, and colorectal cancer, ANGPTL4 inhibits cell growth and angiogenesis [13]."
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"Tube formation, corneal neovascularization, and miles permeability assays were used to prove that ANGPTL4 could suppress both angiogenesis and vascular leakiness [50]."
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"Another study by Okochi-Takada et al. also showed that ANGPTL4 acted as a tumor suppressor and inhibited angiogenesis partly by inhibiting ERK signaling 15."
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"In contrast, another study found that ANGPTL4 expression was significantly lower in HCC tissue than in adjacent normal liver tissue and that ANGPTL4 inhibited tumor angiogenesis and metastasis [32]."
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"XREF_BIBR, XREF_BIBR However, previous studies have shown that ANGPTL4 inhibits angiogenesis and prevents metastasis, XREF_BIBR, XREF_BIBR highlighting a controversial effect of ANGPTL4 on tumour metastasis."
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"Moreover, IL-7 stimulated fibroblasts secreted ANGPTL4, which inhibited angiogenesis of endothelial cells resulting in delayed wound healing."
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"Various studies have also shown that ANGPTL4 expression prevents metastasis and angiogenesis by reducing vascular leakiness , cell motility and invasiveness in different neoplasm types , including melanoma , gastric , lung and colorectal tumors , as well as metastases [ 20-22 ] ."
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"The carboxyl terminus of Angptl4 alone is sufficient to suppress angiogenesis, possibly through inhibiting the Raf/MEK/ERK1/2 MAP kinase pathway in endothelial cells."
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"IL-7 stimulates dermal fibroblasts secreting Angptl4 which inhibits proliferation, migration and angiogenesis of endothelial cells in a paracrine way."
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"For example, orthotopic xenograft model of hepatocellular carcinoma (HCC) showed that ANGPTL4 inhibited tumor growth, invasiveness, metastasis, and angiogenesis, whereas increased apoptosis ."
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"Moreover, ANGPTL4 knockdown further enhanced the angiogenesis, proliferation and migration ability of endothelial cells in the microenvironment (Fig. S1F–H)."
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