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ANGPTL4 inhibits angiogenesis. 25 / 27
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"However, several studies have claimed that ANGPTL4 inhibits vascular angiogenesis and prevents tumor metastasis in melanoma B16F0, lung cancer 3LL [XREF_BIBR] and colon cancer CMT93 [XREF_BIBR] xenograft mouse models; however, contrasting results were observed in breast cancer [XREF_BIBR], renal cell carcinoma [XREF_BIBR], and ovarian cancer [XREF_BIBR, XREF_BIBR] xenograft models, indicating that ANGPTL4 may act as a tissue specific and multifunctional vascular modulator."
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"Decreased ANGPTL4 impairs endometrial angiogenesis during peri-implantation period in patients with recurrent implantation failure."
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"By contrast, in melanoma, lung, and colorectal cancer, ANGPTL4 inhibits cell growth and angiogenesis [13]."
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"On the other hand, several studies showed that increased ANGPTL4 expression could inhibit tumor growth, metastasis, and angiogenesis in melanoma, lung, and colorectal cancers [XREF_BIBR, XREF_BIBR]."
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"Various studies have also shown that ANGPTL4 expression prevents metastasis and angiogenesis by reducing vascular leakiness, cell motility and invasiveness in different neoplasm types, including melanoma, gastric, lung and colorectal tumors, as well as metastases [XREF_BIBR - XREF_BIBR]."
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"This suggested ANGPTL4 can suppress angiogenesis of HCC."
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"Collectively, these observations support a possible role for ANGPTL4 in the promotion of metastasis in UM and provide a foundation for future studies to determine whether combined inhibition of both ANGPTL4 and VEGF could simultaneously target tumor induced angiogenesis and metastasis, and thereby provide more effective therapies for patients with primary and metastatic UM."
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"It has been reported that the C-terminal domain of ANGPTL4 protein inhibits vascular epithelial growth factor (VEGF) and basic fibroblast growth factor (bFGF)-mediated angiogenesis [XREF_BIBR], and SNP rs1044250 is capable of altering the activity of ANGPTL4 C-terminus, therefore, the SNP rs1044250 may lead to a decreased angiogenesis and dysfunctional endothelial repairment."
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"In vivo, ANGPTL4 inhibits angiogenesis and vascular leakiness as well as melanoma cell motility and invasiveness to prevent metastasis."
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"By knocking-out ANGPTL4 using TALENs method, osteoclastogenesis, osteolysis and angiogenesis induced by GCTSCs were significantly suppressed in vitro."
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"While some studies indicate that ANGPTL4 promotes tumorigenesis [XREF_BIBR, XREF_BIBR, XREF_BIBR], other studies suggest that ANGPTL4 inhibits angiogenesis and tumorigenesis [XREF_BIBR, XREF_BIBR, XREF_BIBR] (Box 2)."
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"ANGPTL4 stimulates integrin-dependent survival signals through the activation of NADPH oxidase 1 (Nox1), mimics anchorage conditions and confers anoikis resistance to tumour cells by regulating oncogenic reactive oxygen species (ROS). xref Tumour-derived C-terminal ANGPTL4 (cANGPTL4) binds to integrin α5β1 and activates the downstream PAK/Rac signalling pathway, resulting in endothelial disruption in TGFβ-enhanced lung metastasis of breast cancer. xref , xref However, previous studies have shown that ANGPTL4 inhibits angiogenesis and prevents metastasis, xref , xref highlighting a controversial effect of ANGPTL4 on tumour metastasis."
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"ANGPTL4 induced neovascularization was not inhibited by the VEGF inhibitor PTK787/ZK 222584."
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"However, its biology in experimental systems is still under debate as other studies show ANGPTL4 promotes endothelial barrier integrity, ameliorates tissue injury or tumor metastasis, and inhibits angiogenesis (26–29)."
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"The carboxyl terminus of Angptl4 alone is sufficient to suppress angiogenesis, possibly through inhibiting the Raf/MEK/ERK1/2 MAP kinase pathway in endothelial cells."
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"Various studies have also shown that ANGPTL4 expression prevents metastasis and angiogenesis by reducing vascular leakiness , cell motility and invasiveness in different neoplasm types , including melanoma , gastric , lung and colorectal tumors , as well as metastases [ 20-22 ] ."
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"They showed that ANGPTL4 inhibits vascular endothelial growth factor (VEGF)-induced neovascularization."
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"ANGPTL4 promoted tumor apoptosis and inhibits tumor angiogenesis."
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"They showed that ANGPTL4 inhibits vascular endothelial growth factor (VEGF)–induced neovascularization."
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"Moreover, IL-7 stimulated fibroblasts secreted ANGPTL4, which inhibited angiogenesis of endothelial cells resulting in delayed wound healing."
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"In contrast, some studies have found no precise function for ANGPTL4 in cancer progression or even some of them discovered that the elevated expression of ANGPTL4 prevents tumor growth, invasion, and angiogenesis in melanoma and colorectal cancers 30."
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"XREF_BIBR, XREF_BIBR However, previous studies have shown that ANGPTL4 inhibits angiogenesis and prevents metastasis, XREF_BIBR, XREF_BIBR highlighting a controversial effect of ANGPTL4 on tumour metastasis."
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"However, studies have also shown that increased ANGPTL4 expression inhibits melanoma, lung, and colorectal tumor growth, metastasis, and angiogenesis."
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"However, in melanoma, lung, and colorectal cancer, the induction of ANGPTL4 is reported to inhibit cell growth, angiogenesis, and metastasis [13]."
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"IL-7 stimulates dermal fibroblasts secreting Angptl4 which inhibits proliferation, migration and angiogenesis of endothelial cells in a paracrine way."
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