IndraLab

Statements

USP13 activates MYC. 4 / 10
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"In HCC cell lines, knockdown of USP13 by shRNAs significantly reduced cell growth, and decreased levels of c‐Myc."
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"We found a positive correlation between TRF1 levels and all the stem cell markers with the exception of MYC, although TRF1 was positively correlated with the MYC modulator USP13 (Fang et al., 2017)."
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"Collectively, these data demonstrate that the ubiquitination insensitive mutant of c-Myc is able to rescue the phenotypes caused by USP13 knockdown or FBXL14 overexpression in vitro and in vivo, which supports that USP13 and FBXL14 mediate posttranslational regulation of c-Myc to control the stem cell like phenotype and tumorigenic potential of GSCs."
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"Aurora B and ataxia telangiectasia mutated (ATM) regulate the expression of USP13 via phosphorylation of USP13 at Ser114 and Thr196 to promote the interaction between them, respectively, while the CDC-like kinase 3 (CLK3)-Q607R mutation induces the phosphorylation of USP13 at Tyr708 and promotes its association with c-Myc (43)."
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