IndraLab

Statements

RNF11 binds STAMBP. 10 / 10
1 3 1 | 2 3
sparser
"We have shown that RNF11 binds to AMSH and, in the presence of the E3 ligase Smurf2, promotes the ubiquitination and degradation of the AMSH protein [40]."
16925951
sparser
"It has also been reported that RNF11 binds to AMSH, a deubiquitinating enzyme that antagonizes the inhibitory effect exerted on the signaling pathway of TGF-β by the inhibitory (I-) SMADs, SMAD6 and SMAD7 [ xref ]."
33187263
hprd
No evidence text available
14755250
reach
"We have shown that RNF11 binds to AMSH and, in the presence of the E3 ligase Smurf2, promotes the ubiquitination and degradation of the AMSH protein [40]."
16925951
sparser
"RNF11 binds the DUB protein AMSH and promotes its degradation by the E3-ligase SMURF2-mediated ubiquitination [ xref ]."
33187263
biogrid
No evidence text available
14755250
signor
"RNF11 recruits AMSH to Smurf2 E3 ligase. Smurf2 promotes ubiquitination of AMSH in the presence of wt RNF11. Previously, we have shown that RNF11 interacts with the HECT-type E3 ligases AIP4 and Smurf2. Here, we show that RNF11 binds to AMSH in mammalian cells and that this interaction is independent of the RNF11 RING-finger domain and the PY motif. Our results also demonstrate that AMSH is ubiquitinated by Smurf2 E3 ligase in the presence of RNF11 and that a consequent reduction in its steady-state level requires both RNF11 and Smurf2. RNF11 therefore recruits AMSH to Smurf2 for ubiquitination, leading to its degradation by the 26S proteasome."
14755250
reach
"Here, we show that RNF11 binds to AMSH in mammalian cells and that this interaction is independent of the RNF11 RING-finger domain and the PY motif."
14755250
biogrid
No evidence text available
14755250
biogrid
No evidence text available
14755250