IndraLab

Statements

USP22 binds RCOR1. 4 / 4
| 4
reach
"Ultimately, we demonstrate that GSE1 is required for the recruitment of the deubiquitinase USP22 to the CoREST complex, potentially serving as a scaffold, and that loss of GSE1 inhibits deubiquitination of histone H2B at lysine 120, which was previously shown to facilitate γH2AX formation (11,35)."
37878419
reach
"Binding of USP22 to CoREST was independent of HDAC1 (Figure 6D) and also not affected by treatment with the HDAC inhibitor trichostatin A (TSA) (Supplementary Figure S6D)."
37878419
reach
"One of key requirements in this process seems to be the GSE1-dependent binding of USP22 to CoREST."
37878419
reach
"Of note, we observed that GSE1 is essential for the binding of USP22 to CoREST, suggesting a role as a scaffolder.Why has this multi-eraser complex gone unnoticed in previous research?"
37878419