IndraLab

Statements

USP18 binds IFN receptor. 3 / 3
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"Since we have shown that binding of Usp18 to type I IFN receptor subunit 2 (Ifnar2) is important for Usp18 mediated downregulation of type I IFN signalling, we investigated a potential interaction of Usp18 with the IFN-lambda specific receptor subunit IL-28R1."
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"To exert its function as a negative regulator, USP18 binds to the IFN receptor and JAK complex and attenuates the magnitude of the response."
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"For instance, STAT2-dependent USP18 recruitment to the type I IFN receptor subunit IFNAR2 is required for USP18-mediated receptor dimerization interference [21, 23, 24]."
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