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USP22 decreases the amount of TFRC. 2 / 2
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"In addition, IHC staining of Ki‐67, H2BK120ub and TFRC in frozen sections from all four groups indicated that USP22 knockout promoted H2BK120ub and TFRC levels in transplanted tumours, and inhibited hepatocellular carcinoma malignancy as indicated by Ki‐67 staining, especially after Sorafenib treatment (Figure 8G‒J)."
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"Likewise, the increase of GPX4 protein level, as well as the decrease of TFR1 protein level that caused by USP22 OE in HG-induced INS-1 cells were also partly abrogated by miR-144-3p mimic (Fig. 3L)."
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