IndraLab

Statements

KCNMA1 activates apoptotic process. 28 / 28
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"SLO induces caspase activation and apoptosis of human DC."
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"Among the secreted products of GAS, streptolysin O (SLO) can induce apoptosis in keratinocytes [XREF_BIBR]."
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"SLO induces apoptosis or oncosis in murine and human macrophages and interferes with bacterial killing by macrophages [ 24 , 25 ]."
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"To delineate the cellular process that is triggered by SLO and SLS delivery the involvement of autophagy, apoptosis, and necrosis that are affected by the hemolysin toxins and were shown to be linked to GAS pathogenesis was examined."
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"SLO production by GAS is associated with cytotoxic injury to macrophages in vitro, and SLO has been reported to induce macrophage apoptosis, pyroptosis, and oncosis."
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"It has been established that GAS can kill macrophages, through the activation of an inflammatory programmed cell death pathway mediated by SLS and SLO 81."
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"A general caspase inhibitor blocked SLO induced apoptosis and enhanced macrophage killing of GAS."
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"Treatment with cytochalasin D completely abolished SLO induced DC apoptosis (XREF_FIG), but not the induction of apoptosis by an unrelated stimulus, actinomycin D."
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"Analysis of isogenic mutant strains revealed that SLO production inhibited DC maturation in response to GAS and triggered DC apoptosis."
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"Similarly, SLO can also induce accelerated macrophage apoptosis."
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"SLO also induced apoptosis of mature osteoclasts."
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"However, Bentley et al. reported that S. pyogenes SLO contributed to keratinocyte apoptosis (Cywes Bentley et al., 2005)."
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"Using isogenic mutants deficient in HA and/or SLO, we determined that GAS inhibits DC maturation through two distinct mechanisms : 1) inhibition of bacterial binding and/or phagocytosis by the HA capsule, and 2) SLO mediated induction of DC apoptosis by intracellular GAS."
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"SLO induces apoptosis in macrophages [XREF_BIBR] and DNase degrades NETs [XREF_BIBR, XREF_BIBR] which both facilitate GAS to evade the innate immune system."
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"A previous study showed that SLO secreted by extracellular GAS induces keratinocyte apoptosis by augmenting calcium influx through transmembrane pores [XREF_BIBR]."
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"The BK channel openers NS1619 or tamoxifen significantly induced apoptosis reducing cell viability in cells expressing the combination of the hslo + beta 1 subunits under hyperglycemia conditions suggesting that cloned BK channel directly regulates apoptosis and proliferation of HEK293 cell."
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"SLO also induces apoptosis in mature osteoclasts, suggesting that SLO blocks osteoclast activation during S. pyogenes infection.15 Osteoclasts are essential effectors for infection-related bone destruction."
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"Others have shown that SLO induces oncosis or apoptosis of macrophages."
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"The SLO toxin from S. pyogenes caused apoptosis in primary and cultured macrophages and neutrophils which also showed ultrastructural evidences of mitochondrial membrane remodeling ( Timmer et al., 20[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The CPP conjugated protein delivery system induced apoptosis in only a few cells, but the SLO mediated protein delivery system induced apoptosis in over 4% and 10% of cells (XREF_FIG)."
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"Production of the secreted CDC SLO is strongly associated with the capacity of GAS to incapacitate macrophage function : SLO producing GAS bacteria induce apoptosis of murine and human macrophages in vitro and resist macrophage mediated bacterial killing, in contrast to isogenic SLO deficient mutants."
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"Furthermore, SLO promotes macrophage apoptosis by releasing SLO from the lysosome and causing mitochondrial damage (21, 54)."
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"Therefore, SLO and granF2 may induce apoptosis of host macrophages and thus get access to MDR-TB bacilli whereas intracellular bacteria seem to be protected from the activity of G13.Several reports ha[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"We next tested apoptosis, because other groups reported that SLO can induce apoptosis ."
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"We measured the percentage of apoptotic cells by staining cells with Annexin V and propidium iodide (PI) after challenge with nothing, SLO ML, SLO WT, or PFO followed by LPS stimulation for 4 h or 24 h. PFO, but not SLO, caused a minor, but statistically significant, increase in apoptosis at 4 h following LPS stimulation (Fig. 2C)."
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"We reasoned the KCNMA1 contribute to the GC risk by regulating the key apoptosis gene PTK2."
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"Overexpression of lnc-TSI and KCNMA1 promoted apoptosis and decreased cell viability of sorafenib-treated HCC cells, thus alleviated sorafenib resistance."
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"KCNMA1 induced cell apoptosis."
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