IndraLab
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KCNMA1 activates apoptotic process. 22 / 22
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22
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"We measured the percentage of apoptotic cells by staining cells with Annexin V and propidium iodide (PI) after challenge with nothing, SLO ML, SLO WT, or PFO followed by LPS stimulation for 4 h or 24 h. PFO, but not SLO, caused a minor, but statistically significant, increase in apoptosis at 4 h following LPS stimulation (Fig. 2C)."
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"The BK channel openers NS1619 or tamoxifen significantly induced apoptosis reducing cell viability in cells expressing the combination of the hslo + beta 1 subunits under hyperglycemia conditions suggesting that cloned BK channel directly regulates apoptosis and proliferation of HEK293 cell."
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"Production of the secreted CDC SLO is strongly associated with the capacity of GAS to incapacitate macrophage function : SLO producing GAS bacteria induce apoptosis of murine and human macrophages in vitro and resist macrophage mediated bacterial killing, in contrast to isogenic SLO deficient mutants."