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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

UCHL1 inhibits chaperone-mediated autophagy. 1 / 1

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bel

"UCH-L1 mutations are linked to autosomal-dominant PD, however the mechanism by which it caused the disease is unclear, with conflicting evidence reported for its in vivo functions. Recent studies reveal a role for UCH-L1 in chaperone-mediated autophagy (CMA) and mutant UCH-L1 was shown to inhibit CMA-mediated removal of alpha-synuclein [83]."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...