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UCHL1 inhibits chaperone-mediated autophagy. 1 / 1

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"UCH-L1 mutations are linked to autosomal-dominant PD, however the mechanism by which it caused the disease is unclear, with conflicting evidence reported for its in vivo functions. Recent studies reveal a role for UCH-L1 in chaperone-mediated autophagy (CMA) and mutant UCH-L1 was shown to inhibit CMA-mediated removal of alpha-synuclein [83]."

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UCHL1 inhibits chaperone-mediated autophagy. 1 / 1

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