IndraLab

Statements

SCN5A activates calcium(2+). 11 / 11
| 11
reach
"Sweroside exhibited the strongly protective effect on aconitine-induced cardiac toxicity through inhibiting mRNA expression of NaV1.5, RyR2 and DHPR, elevating mRNA level of SERCA, thus reducing the C[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
35405250
reach
"These observations imply that CaM F90L may cause IVF due to a defective interaction with RyR2 leading to dysregulated SR Ca 2+ release.A detailed description of methods is provided in the Supplementar[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25036739
reach
"Interestingly, the latter two genes were also involved in the entrainment of the circadian clock.The biological process of atrial cardiac muscle cell action potential includes the genes Cacnb2, Scn5a and Kcna5, which modulate calcium, sodium, and potassium transport in excitable membranes, respectively, as well as the involvement of Ank2 in signal transduction."
39369082
reach
"Additionally, DMD EHTs displayed increased expression of genes related to excitation-contraction coupling and regulation of membrane potential (SCN5A, CACNA1G, CACNA1C), which could point toward membrane hyper-excitability and increased Na and Ca currents causing prolongation of action potentials and increased incidence of early after depolarizations."
36003954
reach
"To counteract these changes, IVF models also exhibit increased G , which limit the Ca influx via shortening the action potential duration, and reduced luminal Ca activation of ryanodine receptors and G , which likely reduce automaticity in the presence of enhanced Ca loading."
39297840
reach
"Similarly, inhibition of the late Nav1.5 current could help prevent cellular calcium overload and early afterdepolarizations, both of which are key triggers for torsades de pointes (21)."
40166071
reach
"The phosphorylation level of Nav1.5 and α1 subunit of L-type calcium channel (Cav1.2) can both be increased by CaMKII activation, which further enhances late sodium current (I Na,L ) and L-type calciu[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
32822713
reach
"The observed interacting effects of Scn5a +/DeltaKPQ genotype and age are consistent with increased incidences of alternans in old Scn5a +/DeltaKPQ mice producing an underlying Ca 2+ cycling alternans given age related reductions in myocardial SR Ca 2+ ATPase (SERCA) density 69."
28894151
reach
"The increased mRNA expression levels of DHPR, SCN5A and RyR2 in the aconitine group (P < 0.05) suggested that aconitine could up-regulate L-type voltage-dependent Ca channels (LVDCCs), sarcoplasmic reticulum Ca release channels and Na channels."
30410440
reach
"The first question is how a mutation/variant in SCN5A gene can cause the abnormal calcium handling in BrS‐hiPSC‐CMs."
36881552
reach
"As expected, in vivo matured caprine oocytes also released [Ca 2+ ] i in an oscillatory manner when stimulated by IVF ( Fig. 4 C–E; amplitude 0.3, duration 3 min and spiking interval of 5–59 min)."
16243386