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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

SCN5A activates calcium(2+). 2 / 2

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"The increased mRNA expression levels of DHPR, SCN5A and RyR2 in the aconitine group (P < 0.05) suggested that aconitine could up-regulate L-type voltage-dependent Ca channels (LVDCCs), sarcoplasmic reticulum Ca release channels and Na channels."

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"The observed interacting effects of Scn5a +/DeltaKPQ genotype and age are consistent with increased incidences of alternans in old Scn5a +/DeltaKPQ mice producing an underlying Ca 2+ cycling alternans given age related reductions in myocardial SR Ca 2+ ATPase (SERCA) density 69."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...