IndraLab

Statements

Amlexanox inhibits IKBKE. 14 / 14
1 | 4 1 8
eidos
"Consistent with this view , global knockout of the cGAS-cGAMP-STING downstream target TBK1 ( 37 ) or IRF3 ( 38 ) , or pharmacological inhibition of IkappaB kinase epsilon ( IKKepsilon ) and TBK1 by amlexanox , reduced body weight , enhanced insulin sensitivity , and improved glucose tolerance in obese mice and in a subset of patients with type 2 diabetes ( 34,39 ) ."
31109939
eidos
"Collectively , we found that inhibition of the TBK1 and IKKepsilon by amlexanox is a promising therapeutic strategy to cure liver fibrosis ."
31821710
eidos
"Based on histopathologic analysis using H & E and Sirius-red staining , inhibition of TBK1 and IKKepsilon by amlexanox markedly reduced biliary hyperplasia and collagen deposition in the livers of mice fed with DDC diet ( Figure 2B , C ) ."
31821710
reach
"Amlexanox blocks activity of TBK1 and IKKepsilon with a half maximal inhibitory concentration (IC50) of approximately 1-2 muM."
30791439
reach
"Amlexanox is a specific inhibitor of IKKepsilon and TBK1."
23396211
reach
"Amlexanox, which is known to inhibit TBK1 and IKKepsilon selectively, is an approved drug for the treatment of bronchial asthma, allergic rhinitis, and conjunctivitis in Japan and elsewhere."
29951055
dgi
No evidence text available
reach
"14 We found that amlexanox treatment could inhibit the IKBKE protein and alter the abundance and phosphorylation status of the Hippo pathway proteins in glioma cells."
29048430
reach
"Recently, amlexanox has been shown to inhibit TBK1 and IKKepsilon, both of which are induced in the liver and fat by high-fat diet mediated NF-kappaB activation [XREF_BIBR]."
27353409
eidos
"As more effective therapeutic strategies are urgently needed for treating hepatic fibrosis and cirrhosis , inhibition of TBK1 and IKKepsilon by amlexanox may be a promising therapeutic strategy to cure fibrosis , which could allow for remodelling and regression of fibrosis ."
31821710
reach
"Amlexanox Amlexanox is an inhibitor of noncanonical IkappaB kinases IKK-epsilon and TANK binding kinase 1."
29247356
reach
"Recently, Reilly et al. [XREF_BIBR] discovered a small molecule inhibitor of IKKepsilon and TBK1 kinases called amlexanox, which has been shown to selectively inhibit both IKKepsilon and TBK1."
27145266
reach
"Blocking TBK1 and IKKepsilon during transduction of NK cells enabled their efficient transduction by VSV-G LVs as judged by YFPexpression of 40-50%, with half maximal effective concentrations of 1.1 microM (MRT67307), 5 microM (BX-795) and 24.8 microM (amlexanox)."
34119434
trips
"Amlexanox Enhances Temozolomide-Induced Antitumor Effects in Human Glioblastoma Cells by Inhibiting IKBKE and the Akt-mTOR Signaling Pathway."
33644550