IndraLab

Statements

OTULIN inhibits inflammatory response. 10 / 10
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"Finally, the numerous other upregulated cytokines in LysMCre-OtulinLacZ and flox mice, which includes anti-inflammatory IL-10, will generate a delicate balance of responses, enabling these mice to deal with inflammation induced by loss of OTULIN."
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"Deletion of Otulin in Mouse Immune Cells Drives Acute Systemic Inflammation."
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"OTULIN inhibits RIPK1-mediated keratinocyte necroptosis to prevent skin inflammation in mice."
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"In an acute model, induced loss of OTULIN in immune cells leads to multi-organ inflammation and deterioration of animals within a few days; this can be ameliorated by anti-TNF, but not by neutralization of other upregulated cytokines."
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"Interestingly, conditional deletion of otulin in myeloid cells, but not T or B cells, causes systemic inflammation, neutrophil infiltration, and multi-organ inflammation in mouse models."
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"OTULIN Prevents Liver Inflammation and Hepatocellular Carcinoma by Inhibiting FADD- and RIPK1 Kinase Mediated Hepatocyte Apoptosis."
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"OTULIN overexpression attenuated microglia activation in LPS induced brain inflammation."
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"While loss of OTULIN leads to excessive inflammation through accumulation of linear-Ub, germline deficiencies of LUBAC also result in autoinflammation."
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"Recent work suggested that OTULIN can limit inflammation by deubiquitinating LUBAC [9]."
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"OTULIN limits cell death and inflammation by deubiquitinating LUBAC."
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